Itchy skin may signal serious diseases. Six hidden causes of persistent itching

Liver diseases: Liver conditions often cause itchy skin, especially in the advanced stages. The liver's role includes detoxification and processing numerous substances, including bile. With liver diseases like cirrhosis or inflammation, bile may build up, leading to itchiness. The itching sensation can manifest on the palms or feet and other body parts.

Thyroid diseases: Such conditions, including hypothyroidism and hyperthyroidism, can interfere with skin metabolism. Hypothyroidism can cause the skin to become dry and rough, often leading to itching. Conversely, hyperthyroidism may increase blood flow to the skin, resulting in redness and feeling itchiness.

Blood diseases: Overproduction of red blood cells can lead to increased blood flow, potentially causing itchiness. Leukemia and other blood cancers might cause itching due to the increased production of histamine, a compound that triggers allergic reactions.

Kidney failure: Chronic inflammation, imbalance within endogenous opioids, and excessive activation of mast cells leading to increased histamine release could cause itching during kidney failure.

Diabetes: This condition can cause itchy skin in several ways. High glucose levels can primarily lead to skin infections, often accompanied by itching. Plus, diabetes often results in skin dryness.

Multiple sclerosis: This disease attacks the nervous system. Given that nerves play a crucial role in the sensation of itching, some individuals with multiple sclerosis may experience chronic itching, even though it isn't the most common symptom.

All mentioned diseases require specialized treatment. If you experience persistent itching without a clear cause determined by a dermatologist, it may be worth consulting your primary care physician for further diagnostic evaluation.