Herpes link to Alzheimer's opens doors for new treatments
Scientists from the University of Pittsburgh have discovered a surprising connection between Alzheimer's disease and the herpes simplex virus type 1 (HSV-1). Their study suggests that viral infections may play a role in developing this condition.
Researchers at the University of Pittsburgh found that the herpes simplex virus type 1 (HSV-1) may be linked to the development of Alzheimer's disease. Studies indicate that viral infections can play a significant role in this process, with special attention paid to the tau protein, which accumulates in the brain.
Dr. Or Shemesh, the primary author of the research featured in Cell Reports, highlights that the conventional perception of tau protein as entirely harmful could be inaccurate. According to Dr. Shemesh, the findings suggest that tau protein may initially play a role in the brain's immune defense system.
These findings could lead to the development of new treatment methods targeting infections and the brain's immune response.
The discovery sheds light on the intricate relationship between infections, immune responses, and neurodegenerative processes, providing fresh perspectives and identifying potential targets for the development of novel therapies, the expert explains.
Viral proteins in patients' brains
The research team identified HSV-1-related proteins present in samples taken from the brains of individuals with Alzheimer's disease. Large amounts of viral proteins were associated with characteristic pathological changes occurring during the disease.
Further studies on miniature human brain models showed that HSV-1 infection could affect tau protein levels and regulate its function. This mechanism appears to protect neurons from death after infection.
Although the exact mechanisms of HSV-1's impact on tau protein and Alzheimer's disease development are unknown, scientists plan to conduct further research. Their goal is to test therapeutic strategies targeting viral proteins or modulating the brain's immune response.
Researchers also want to check if similar mechanisms occur in other neurodegenerative diseases, such as Parkinson's disease and amyotrophic lateral sclerosis (ALS).
Many of us have this virus
The World Health Organization indicates that most of the population carries the herpes virus, which means that the increased risk of developing dementia affects many people.
The link between viral infections and neurodegenerative diseases has been interesting since the early 20th century. Alzheimer's disease is one of the major health challenges of the modern world, and the protein-protecting mechanisms related to it, such as tau protein, are still being studied.
